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$50 billion

Dutch Kidney foundation
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€111 billion a year in Europe and $318 billion in the United States

American Heart association ( 2017) Cardiovascular Disease ; a costly burden for America- projections through 2035; Washington DC
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1 million patients

J Thorac Dis. 2018 Mar; 10(3) Fifty years of coronary artery bypass grafting
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17.9 million deaths each year, growing at a rate of 9% annually

The World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC)
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20% of such grafts fail within one year

Allison B. Hall and Emmanouil S. Brilakis . J Thorac Dis. 2019 May; 11(Suppl 9): S1441–S1444. Saphenous vein graft failure:…
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3.5 million patients

World Health Organization (WHO)
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850 million

Kitty J Jager 1, Csaba Kovesdy 2, Robyn Langham 3, Mark Rosenberg 4, Vivekanand Jha 5 6, Carmine Zoccali 7…
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access occlusion (clotting)

3. Roetker, NS et al. Hemodialysis Vascular Access and Risk of Major Bleeding, Thrombosis, and Cardiovascular Events: A Cohort Study,…
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alternatives are not viable

2. Wilcox TA. Catheter-related bloodstream infections. Semin Intervent Radiol. 2009 Jun;26(2):139-43. doi: 10.1055/s-0029-1222458. PMID: 21326505; PMCID: PMC3036424.
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average 2 to 4

American College of Cardiology
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Study Number
NCT05473299
www.clinicaltrials.gov

Study Sponsor
Xeltis
www.xeltis.com

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